What’s The Difference Between Sculptra, Radiesse, and Hyaluronic Acid Fillers for Non-Surgical BBL?

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The world of cosmetic surgery is competitive, and the constant push for new and fresh procedures is hard to keep up with. If you’re looking at nonsurgical cosmetic treatment options, the benefit is that you have more options available than ever. Non-surgical buttocks injections are often a great fit for slimmer patients without much body fat, who aren’t suitable for fat transfer surgery. The procedure requires minimal downtime and results last up to a few years. The best way to select the right product for your needs is by consulting an experienced injector. In the meantime, here’s what to know about our best three best injectable options at Glamour Medical Aesthetics.

What’s The Difference Between Sculptra BBL, Radiesse BBL, and Hyaluronic Acid Fillers BBL?

Sculptra, Radiesse, and hyaluronic acid fillers (Juvéderm, Revanesse Versa, Restylane Lyft, and more) are some of the leading names in filler technologies. It can be easy to think they’re all the same, but there are some key differences that may mean one is better for you than the other.


Sculptra is an injectable, FDA-approved biostimulator that is known by many to add volume to the face, improve cellulite, and add volume to buttocks. Sculptra stands apart from many other fillers because it’s made with an active ingredient called poly-L-lactic acid (PLLA). This allows it to stimulate collagen production in the skin with no side effects or complications. As the product is injected, it triggers your body to stimulate collagen over time, leaving some of the longest-lasting results.

Benefits of Sculptra for buttocks enhancement:

  • Restore collagen production and increase skin laxity
  • Reduce cellulite
  • Achieve a fuller, lifted butt and curvier shape
  • Recontour your hips and buttocks to create a more flattering shape
  • Reduce the appearance of hip dips
  • Smooth out BBL dimples
  • Experience minimal downtime and return to normal activities after 24 hours


Radiesse is a calcium hydroxylapatite filler that has been FDA-approved for over 10 years and has some very noticeable benefits for the face and body. The main benefit of Radiesse is to improve skin texture, shape, lift, and contour. Radiesse can be used on the face, neck, decolletage, upper arms, back of the hands, abdomen, elbows and above the knees. It can reduce cellulite, add volume to the buttocks, smooth out BBL dimples, and improve hip dips. It works similarly to Sculptra by stimulating collagen.

One significant difference between Sculptra and Radiesse is that they have very different consistency. Although you can’t compare Radiesse (Calcium hydroxylapatite, or CaHA) to Sculptra (polylactic acid or PLLA) molecules because they are completely different molecules, they are both considered bio-stimulators.

Radiesse doesn’t use the immune system for biostimulation. Radiesse works directly with the fibroblasts to trigger the natural process of collagen and elastin generation versus Sculptra which does rely on the immune system for biostimulation.

Radiesse is a regenerative, versatile product which can be injected “as is” for instant volume resulting in contour and lift as well as biostimulating the production of type 1 collagen, type 3 collagen, and elastin both “as is” and diluted.

Sculptra doesn’t result in instant volume because it takes time for your body to produce collagen. Volume is gradually developed over a few months by the stimulation of collagen. There is no biostimulation of elastin production with Sculptra. Results are dependent on the patient’s compliance with after treatment massages.

Radiesse gives immediate volume (gratification) with no massage post treatment by the patient.

Hyaluronic Acid Fillers

The third option is hyaluronic acid fillers (like Restylane, Juvéderm, Revanesse Versa, HYAcorp, Genefill, and many others) that you may have heard about before. Hyaluronic acid fillers contain hyaluronic acid. Hyaluronic acid is found naturally throughout the body, with the highest concentrations in the joints, eyes, and skin. In the skin, hyaluronic acid draws in water and increases the volume of the treated area. Hyaluronic acid fillers do not stimulate collagen but the benefit is that they can be used in more diverse areas by adding an instant volume lasting up to 2 years.

Hyaluronic acid fillers can improve facial fine lines and wrinkles, add volume to cheeks, lips, forehead, and temples, and improve the chin and build the jawline.

Hyaluronic acid fillers can also be used on the neck, back of the hands, calves, and add instant volume to the buttocks and hip dips. Results are instant with no downtime and post-treatment massage is not required.

Which Filler is Right for Me?

It can be hard to determine which filler will best achieve your goals without consulting an expert. Still, there are benefits to each. As mentioned above, Sculptra is one of the few FDA-approved fillers that stimulates collagen production. It’s hard to top Sculptra’s long-lasting results. However, Radiesse is an excellent choice for those who want the same benefits as Sculptra but with instant volume. Hyaluronic acid fillers are the most versatile of the three choices since they can be used almost anywhere on the face and body and can produce instant volume – however, they don’t have the benefits of biostimulation.

Ultimately, the right filler for your goals depends on factors like your specific goals and medical history. During your consultation, you’ll discuss all facets of your treatment and determine the best approach.

Schedule an Appointment

If you’re interested in exploring more with your filler options, contact our Miami-area office by calling or filling out our online contact form.